About Thalassemia

A Basic Description | Alpha Thalassemia | Beta Thalassemia | Other Forms of Thalassemia | Downloadable Brochures on Thalassemia and its complications

Thalassemia: A Basic Description

Thalassemia is the name of a group of genetic blood disorders. To understand how thalassemia affects the human body, you must first understand a little about how blood is made.

Hemoglobin is the oxygen-carrying component of the red blood cells. It consists of two different proteins, an alpha and a beta. If the body doesn’t produce enough of either of these two proteins, the red blood cells do not form properly and cannot carry sufficient oxygen. The result is anemia that begins in early childhood and lasts throughout life.

Since thalassemia is not a single disorder but a group of related disorders that affect the human body in similar ways, it is important to understand the differences between the various types of thalassemia.

Alpha Thalassemia

People whose hemoglobin does not produce enough alpha protein have alpha thalassemia. It is commonly found in Africa, the Middle East, India, Southeast Asia, southern China, and occasionally the Mediterranean region.

There are four types of alpha thalassemia that range from mild to severe in their effect on the body.

Silent Carrier State. This condition generally causes no health problems because the lack of alpha protein is so small that the hemoglobin functions normally. It is called “silent carrier” because of how difficult it is to detect. Silent carrier state is “diagnosed” by deduction when an apparently normal individual has a child with hemoglobin H disease or alpha thalassemia trait.

Hemoglobin Constant Spring. This is an unusual form of Silent Carrier state that is caused by a mutation of the alpha globin. It is called Constant Spring after the region of Jamaica in which it was discovered. As in silent carrier state, an individual with this condition usually experiences no related health problems.

Alpha Thalassemia Trait or Mild Alpha Thalassemia. In this condition, the lack of alpha protein is somewhat greater. Patients with this condition have smaller red blood cells and a mild anemia, although many patients do not experience symptoms. However, physicians often mistake mild alpha thalassemia for iron deficiency anemia and prescribe iron supplements that have no effect on the anemia.

Hemoglobin H Disease. In this condition, the lack of alpha protein is great enough to cause severe anemia and serious health problems such as an enlarged spleen, bone deformities and fatigue. It is named for the abnormal hemoglobin H (created by the remaining beta globin) that destroys red blood cells.

Hemoglobin H-Constant Spring. This condition is more severe than hemoglobin H disease. Individuals with this condition tend to have a more severe anemia and suffer more frequently from enlargement of the spleen and viral infections.

Homozygous Constant Spring. This condition is a variation of hemoglobin H-Constant Spring that occurs when two Constant Spring carriers pass their genes on to their child (as opposed to hemoglobin H Constant Spring, in which one parent is a Constant Spring Carrier and the other a carrier of alpha thalassemia trait). This condition is generally less severe than hemoglobin H Constant Spring and more similar to hemoglobin H disease.

Alpha Thalassemia Major (Hemoglobin Bart’s Hydrops Fetalis). In this condition, there are no alpha genes in the individual’s DNA, which causes the gamma globins produced by the fetus to form an abnormal hemoglobin called hemoglobin Barts. While alpha thalassemia major is an extremely serious condition, treatment and survival is possible with in utero blood transfusions. Individuals born with alpha thalassemia major are treated with lifelong blood transfusions and other medical care. (UCSF Benioff Children’s Hospital has created two brochures on alpha thalassemia major and treatment options, including a new clinical trial exploring in utero stem cell transplantation. The parents brochure is here and the healthcare providers brochure is here.)

Beta Thalassemia

People whose hemoglobin does not produce enough beta protein have beta thalassemia. It is found in people of Mediterranean descent, such as Italians and Greeks, and is also found in the Arabian Peninsula, Iran, Africa, Southeast Asia and southern China.

There are three types of beta thalassemia that also range from mild to severe in their effect on the body.

Thalassemia Minor or Thalassemia Trait. In this condition, the lack of beta protein is not great enough to cause problems in the normal functioning of the hemoglobin. A person with this condition simply carries the genetic trait for thalassemia and will usually experience no health problems other than a possible mild anemia. As in mild alpha thalassemia, physicians often mistake the small red blood cells of the person with beta thalassemia minor as a sign of iron-deficiency anemia and incorrectly prescribe iron supplements.

Thalassemia Intermedia. In this condition the lack of beta protein in the hemoglobin is great enough to cause a moderately severe anemia and significant health problems, including bone deformities and enlargement of the spleen. However, there is a wide range in the clinical severity of this condition, and the borderline between thalassemia intermedia and the most severe form, thalassemia major, can be confusing. The deciding factor seems to be the amount of blood transfusions required by the patient. The more dependent the patient is on blood transfusions, the more likely he or she is to be classified as thalassemia major. Generally speaking, patients with thalassemia intermedia need blood transfusions to improve their quality of life, but not in order to survive.

Thalassemia Major or Cooley’s Anemia. This is the most severe form of beta thalassemia in which the complete lack of beta protein in the hemoglobin causes a life-threatening anemia that requires regular blood transfusions and extensive ongoing medical care. These extensive, lifelong blood transfusions lead to iron-overload which must be treated with chelation therapy to prevent early death from organ failure.

Other Forms of Thalassemia

In addition to the alpha and beta thalassemias, there are other related disorders that occur when the gene for alpha or beta thalassemia combines with an abnormal or mutant gene.

E Beta Thalassemia. Hemoglobin E is one of the most common abnormal hemoglobins. It is usually found in people of Southeast Asian ancestry, such as Cambodians, Vietnamese and Thai. When combined with beta thalassemia, hemoglobin E produces E beta thalassemia, a moderately severe anemia which is similar in symptoms to beta thalassemia intermedia.

Sickle Beta Thalassemia. This condition is caused by a combination of beta thalassemia and hemoglobin S, the abnormal hemoglobin found in people with sickle cell disease. It is commonly found in people of Mediterranean ancestry, such as Italians, Greeks and Turks. The condition varies according to the amount of normal beta globin produced by the beta gene. When no beta globin is produced by the beta gene, the condition is almost identical with sickle cell disease. The more beta globin produced by the beta gene, the less severe the condition.

Downloadable Brochures on Thalassemia and Its Complications

Downloadable pdf brochures about thalassemia and various complications associated with the disorder can be accessed by clicking on the links below.

  1. The COVID-19 Pandemic and Thalassemia

    The COVID-19 Pandemic and Haemoglobin Disorders

    Health and Nutrition Short Guide for COVID-19 Pandemic

    FAQs Regarding the Impact of the COVID-19 Pandemic on Individuals with Thalassemia

    COVID-19 and Thalassemia: A Position Statement of the International Thalassaemia Federation

  2. Thalassemia Information

    An Introduction to Beta-Thalassemia Major

    An Introduction to Beta-Thalassemia Intermedia (English, Spanish)

    What is Hemoglobin E (English, BengaliBurmese, Cambodian, Chinese, Hmong, Karen, LaotianThaiVietnamese)

    What is Hemoglobin H (English, Burmese, Cambodian, Chinese, SpanishVietnamese)

    Thalassaemia from ‘A’ to ‘Z’: A Comprehensive e-Glossary for Patients with Thalassaemia (created by the Thalassaemia International Federation (TIF))

  3. Thalassemia Trait Information

    Why Should You Care About Thalassemia? (English, Chinese)

    Have You Been Tested for Alpha Thalassemia Trait? (English, Cambodian, Chinese, French, Hmong, Karen, Spanish, Vietnamese)

    Have You Been Tested For Beta Thalassemia Trait? (English, Arabic, Bengali, Cambodian, Chinese, Greek, Hindi, Karen, Spanish, Swahili, Thai, Urdu, Vietnamese)

    What is Thalassemia Trait? (English only, English/Chinese (bilingual))

    What Should I Know About Thalassemia? (English, Chinese, Karen)

  4. Thalassemia-Related Complications

    Pulmonary Hypertension in Thalassemia

    Transfusion Issues in Thalassemia

    Low Bone Mass in Thalassemia

    Cardiac Issues in Thalassemia

    Diabetes and Thalassemia

    Hepatitis and Liver Issues in Thalassemia

    Thalassemia and the Spleen

    Fertility and Pregnancy in Thalassemia

  5. Thalassemia-Related Tests and Procedures/Comprehensive Care

    Non-Invasive Iron Measurements

    What to Expect When You Go For a MRI for Heart or Liver Iron

    Comprehensive Care Checklist for Thalassemia

    Thalassemia Treatment Centers

    Information on Gene Therapy and Gene Editing

    Gene Therapy in B-thalassemia

    Bone Marrow Transplantation in B-thalassemia (TIF Publication)

  6. Nutrition in Thalassemia

    Zinc – An Informational Pamphlet for Patients with Thalassemia – created by UCSF Benioff Children’s Hospital Oakland

    Zinc – An Informational Pamphlet for Care Providers of Individuals with Thalassemia – created by UCSF Benioff Children’s Hospital Oakland

  7. Guides/Toolkits for Those Living with Thalassemia

    A Guide to Living with Thalassemia

    School Toolkit for People with Transfusion-Dependent Thalassemia

  8. Thalassemia Standards of Care Guidelines

    Thalassemia Standards of Care Guidelines- Children’s Hospital & Research Center Oakland

    TIF 2021 Guidelines for the Management of Transfusion-Dependent Thalassaemia

    TIF 2017 Guidelines for the Management of Non-Transfusion-Dependent Thalassaemia

  9. Thalassemia Management Checklists

    Monitoring Deferasirox Therapy

    Guidelines for Managing Transfusion Therapy for Thalassemia

    Monitoring of Iron Overload in Transfusion-Dependent Thalassemia (TDT)

  10. Thalassemia Materials for Children

    All About Thalassemia – created by TIF (English, Arabic, Bengali, ChineseMalay, Myanmar, Sinhala, Spanish, Turkish)

    Cooley’s Anemia Foundation Storybook

  11. Information about the Cooley’s Anemia Foundation (CAF)

    How to Register Online with CAF

    CAF New Patient Registration Brochures

    CAF: Leading the Fight Against Thalassemia

    What is Cooley’s Anemia and the Cooley’s Anemia Foundation?

  12. Health Messaging Postcards

    Know Your Numbers!

    She Has Thalassemia and Still Runs Half-Marathons

    You Are Your Child’s Best Advocate

    When Iron Gets Out of Balance

    Being Adherent to Thalassemia Treatment Has a Big Pay-off

    Don’t Wait for Your Heart to Tell You About Iron

    Planning a Trip This Summer?

    Getting Your Child Ready for Back-to-School?

    Flu Season Is Coming

    Flu Season is Here

    Testing for Low Bone Mass Helps Prevent Fractures

    Exercise is Important for Optimal Health

    Pregnancy Health Message

    Temporarily Suspending Chelation During Fever

    Have You Chelated Today?

    It’s Never Too Late to Start Being Physically Active

    Partner with Your Healthcare Team to Take Charge of Your Health

    Keep Calm and Chelate

    Chelation Therapy Gave Me New Life

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